Disregard the suggestion to "blend" Black Powder, and Smokeless!!!. The max charge on Your pistol is determined by wehter it is steel or brass framed. A brass framed Colt is probably good for about 25gr of FFg pyrodex, or 20gr of FFg BP. A brass framed revolver should use appx 5gr less due to the fact the frame will stretch out of shape under recoil. There is no top strap on the Colts so all the forces concetrate on the pins at the boottom of thframe and the "Takedown Key"
Sorry about the acronyms PITA = Pain In The Arse.
Oxo Wonder wads are a small felt pad that goes over the powder charge, and under the ball, they are loaded with IIRC silicone and act as wadding to seal off any potential flashovers.
Pyrodex is a little bit harder to ignite then BP, but easier, more forgiving to store, and easier to find. Stores that sell reloading supplies can sell pyrodex, but a special permit is required for BP as it is still classified as a "Low Explosive"
I enjoy using my revolvers very much, infact I carry my 1858 when I go deer hunting during "Muzzleloader" season. We are "Blessed" with large groups of roaming dog packs out here, and I will turn a deer hunt into a dog hunt in a heartbeat.The important thing is to keep it safe, and work up to a load that you are comfotable with.
I REPEAT do not mix Smokeless, and Black Powder, as the Smokeless is going to over pressurize your chambers. The only muzzleloader that are safe for this are a couple of newer ones designed to cheat durring primitive weapons season.