Let's see? Never had a bad S&W - except, if you want to count, a Model 19 I blew up, once, while using Super Vel ammo.
My two favorite S&W revolvers are the Model 27 and the Model 29. I own several of each; and I find it impossible to decide which model I like better. They're both, 'N' frames; but each caliber has its distinct advantages. I love the 44mag for long range pistol shooting; I've tried shooting PPC matches with it - No good, way too slow. For PPC, I'll stick with the Model 27 and 357mag. cartridges loaded way down to, almost, wadcutter velocity.
In the, 'If I ruled the world' catagory: I wish S&W made a strong semi-automatic pistol. I own a beautiful customized Model 59; but I have no illusions - It'll never run with a Colt Government Model.
S&W M66, I have conservatively 40,000+ rds of .38+P through mine since I bought it back in '86. Spent a year using it as a competition gun in the revolver category of IPSC. Minimal repairs required in 34 years. Can use with "powder puff" loads to train new shooters of if required can take down medium sized game.
The one I've used the most is a 4" 681 that I've had for 25-27 years; bought to replace a 4" 586 as a more weather-resistant 'woods gun'. My favorite S&W now is a 986 Performance Center revolver; a 7-shot 9mm that uses moon clips.